Switching the Conductance of a Molecular Junction using a Proton Transfer Reaction

A novel mechanism for switching a molecular junction based on a proton transfer reaction triggered by an external electrostatic field is proposed. As a specific example to demonstrate the feasibility of the mechanism, the tautomers [2,5-(4-hydroxypyridine)] and {2,5-[4(1H)-pyridone]} are considered. Employing a combination of first-principles electronic structure calculations and Landauer transport theory, we show that both tautomers exhibit very different conductance properties and realize the "on" and "off" states of a molecular switch. Moreover, we provide a proof of principle that both forms can be reversibly converted into each other using an external electrostatic field.Comment: 14 pages, 5 figure

EDGE: a code to calculate diffusion of cosmic-ray electrons and their gamma-ray emission

The positron excess measured by PAMELA and AMS can only be explained if there is one or several sources injecting them. Moreover, at the highest energies, it requires the presence of nearby ($\sim$hundreds of parsecs) and middle age (maximum of $\sim$hundreds of kyr) source. Pulsars, as factories of electrons and positrons, are one of the proposed candidates to explain the origin of this excess. To calculate the contribution of these sources to the electron and positron flux at the Earth, we developed EDGE (Electron Diffusion and Gamma rays to the Earth), a code to treat diffusion of electrons and compute their diffusion from a central source with a flexible injection spectrum. We can derive the source's gamma-ray spectrum, spatial extension, the all-electron density in space and the electron and positron flux reaching the Earth. We present in this contribution the fundamentals of the code and study how different parameters affect the gamma-ray spectrum of a source and the electron flux measured at the Earth.Comment: Presented at the 35th International Cosmic Ray Conference (ICRC2017), Bexco, Busan, Kore

Prospects for the Observation of Primordial Black Hole evaporation with the Southern Wide Field of View Gamma-ray Observatory

Primordial Black Holes (PBHs) are remnants of objects formed in the early Universe. Their lifetime is an increasing function of their mass, so PBHs in the right mass range can end their lives in an evaporation event that is potentially detectable by our instruments now. This evaporation may result in a $\gamma$-ray flash that can be detected by the current generation of Very-High-Energy $\gamma$-ray detectors. The Southern Wide field of view Gamma-ray Observatory (SWGO) will be part of the next generation of these instruments. It will be able to establish limits on PBH evaporations for integration windows between 0.5 and 5 s, in a radius of 0.25 pc around the Earth, being sensitive to a rate of the order of $\sim$50 pc$^{-3}$ yr$^{-1}$, more than one order of magnitude more constraining than the currently established best limits.Comment: Accepted by JCA

Genetic and clinical peculiarities in a new family with hereditary hypophosphatemic rickets with hypercalciuria: a case report

Hereditary hypophosphatemic rickets with hypercalciuria is a rare autosomal recessive disorder (OMIM #241530), characterized by decreased renal phosphate reabsorption that leads to hypophosphatemia, rickets, and bone pain; hypophosphatemia is believed to stimulate 1,25 dihydroxyvitamin D synthesis which, in turn, results in hypercalciuria. Hereditary hypophosphatemic rickets with hypercalciuria is caused by loss-of-function in the type 2c sodium phosphate cotransporter encoded by the SLC34A3 gene. This report shows a family with a non-previously identified mutation in the SLC34A3 gene and exhibiting mild and different manifestations of HHRH. The probandus had hypophosphatemia, elevated serum 1,25 dihydroxyvitamin D concentrations, high serum alkaline phosphatase levels, hypercalciuria and nephrocalcinosis. The other members of the family presented some of these alterations: the mother, hypercalciuria and high 1,25 dihydroxyvitamin D concentrations; the son, hypercalciuria, high 1,25 dihydroxyvitamin D values and elevated alkaline phosphatases; the father, high alkaline phosphatases. The genetic analysis revealed the existence of a single mutation (G78R) in heterozygosis in the SLC34A3 gene in the probandus, her mother and her brother, but not in the father. These findings suggest that he mutation in heterozygosis likely gave rise to a mild phenotype with different penetrance in the three relatives and also indicates that the elevation of 1,25 dihydroxyvitamin D does not result from hypophosphatemia. Thus, this family raises some issues on the transmission and pathophysiology of hereditary hypophosphatemic rickets with hypercalciuria

Plywood Industry by Using Eco-efficiency Approach and LIA- Wood Balance Sheet Program

The general purposes of this study were to improve the efficiency of wood utilization and to create wood’s value added for plywood industry. To achieve the above purposes a strategy for Agro forestry Industry should be develop based on eco-efficiencyprinciples. The details of targets were: (1). to analyze critical factors in plywood industry management regarding to eco-efficiency implementation, (2) to analyze production technology that is used in plywood industry, and (3). to design a developing strategy of integrated plywood industry based on eco-efficiency principles. The result of this study show that the key factors for plywood management’s policy was environmental awareness; material utilization; and international issues. The production technology of all plywood industry in Indonesia is relatively similar. They are using the machineries of the 80’s and have the similar working procedures. The kinds of wood wastes generated from plywood industry were classified into log end, reject log end, green veneer waste, and others. The wood waste was calculated 49.52% released from 100% input log in plywood industry. There are three strategy of integrated plywood industry based on eco-efficiency, namely (1) selecting and managing of environmental impact, showing three kinds of waste which affect the environment (2) Improvement the plywood manufacturing technology, showing the newinnovation technology or process control management and (3) Development of new product from wood waste. Wood waste can be used to produce block board, laminated board, handicraft, and others